![]() These tests were also evaluated for detection of epsilon toxin in different matrices: milk and tap water for biological threat detection, serum, stool and intestinal content for human or veterinary diagnostic purposes. With these antibodies, we have developed highly sensitive tests, overnight and 4-h sandwich enzyme immunoassays and an immunochromatographic test performed in 20 min, reaching detection limits of at least 5 pg/mL (0.15 pM), 30 pg/mL (0.9 pM) and 100 pg/mL (3.5 pM) in buffer, respectively. Three of them neutralize the cytotoxic effects of epsilon toxin in vitro. We have produced and characterized five monoclonal antibodies against common epitopes of epsilon toxin and prototoxin. In the case of a bioterrorist attack, there will be a need for a rapid, sensitive and specific detection method to monitor food and water contamination by this toxin, and for a simple human diagnostic test. It is the third most potent clostridial toxin after botulinum and tetanus toxins and is thus considered as a potential biological weapon classified as category B by the Centers for Disease Control and Prevention (CDC). To learn more about our Culture Building Behaviours and what it’s like to work at a company where cultural and scientific excellence combine to deliver powerful diagnostics, visit Unilabsand the Care Big blog.Epsilon toxin is one of the four major toxins of Clostridium perfringens. We aim to be at the heart and start of all effective treatment decisions for patients around the world. ![]() Housed in state-of-the-art laboratory facilities the Discovery and Metabolism services group utilises high-resolution mass spectrometers (Waters Vion IMS QTof, Thermo LTQ Orbitrap and Waters Q-ToF), SCIEX TQ 6500+, API 40 LC-MS/MS systems, Waters Acquity UPLC, Agilent 1290 Hi-Res LC and Hamilton Microlab Star Robotic systems.Īs a part of Unilabs, Europe’s leading provider of digitally driven diagnostics, we have a CARE BIG culture. Our Discovery and Metabolism Services group is at the renowned Discovery Park, Sandwich, Kent. All our services are supported by the latest LIMS, electronic laboratory notebook and IT systems. Our immunoassay facility is equipped with the latest automated systems (MSD) and plate reading technology. Our in-house LC-MS/MS laboratory equipment includes Waters Xevo TQ-XS (UniSpray), Xevo TQ-S, SCIEX TQ 6500+, API 50 LC-MS/MS systems, Hamilton Microlab Star robots, Spark Holland Symbiosis, Shimadzu Nexera, Waters UPC2 and Waters Acquity UPLC I-Class systems. ![]() Located on the outskirts of York, we have a state-of-the-art, purpose-built laboratory and office facilities. Responsible Scientists (Study Directors) and Scientists.Our professional teams cover the following areas: In York, we use LC-MS/MS and immunoassay techniques to perform regulated bioanalysis. At our site in Sandwich, Kent we conduct in vitro ADME, biotransformation and discovery bioanalysis studies. York Bioanalytical Solutions has two sites where we support drug development. Our performance and reward systems are reviewed regularly to ensure we provide a competitive salary and benefits package that reflects our industry. We pride ourselves on a highly scientific and professional focus with a friendly and relaxed atmosphere. We understand the need for a healthy work/life balance and therefore offer flexible working hours for our full and part-time opportunities. A range of internal and external training programs are available that support continuous professional growth. Development opportunities are actively promoted across our business. We recognise the importance of providing an environment to our employees in which the individual feels valued and able to develop to the best of their abilities. We believe that competitive advantage is achieved through our service and our people, and we are constantly looking for individuals who can add value to our teams. The high standards that distinguish our service also apply to the individuals we recruit. York Bioanalytical Solutions (part of Unilabs) has built a prestigious reputation based on consistent quality. As the premier, independent, European-based provider of bioanalytical services to the world’s pharmaceutical industry, we have strong ideas about how our employees help us provide top-quality, scientific service to our clients. ![]()
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